Sam Magee and Chloe Magee lost out in the last 16 of the BWF Tour Super 100 event in Orleans, France on Thursday.
The siblings bowed out to Indonesian pairing Rehan Naufal Kusharjanto and Lisa Ayu Kusumawati with scores of 23-21, 21-15, 21-16.
The Irish pair entered the $75,000 prize-winning event as the sixth seed but their victors will now advance to the semi-finals of the competition.